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Among abundant women at aerial accident for trisomy 21, assuming cell-free DNA (cfDNA) screening tests followed by invasive testing back acceptable did not crop statistically cogent reductions in abortion ante back compared with invasive testing procedures alone, according to a abstraction appear in JAMA. 

A accumulation of French advisers conducted a 2-year, nationwide, 1:1 randomized balloon (NCT Identifier: NCT02127515) to yze ante of abortion afterwards either cfDNA testing with invasive procedures performed afterwards acquiescent a absolute ysis aftereffect vs actual invasive testing procedures. Women included in the abstraction (n= 2111) had a accident for trisomy 21 amid 1 in 5 and 1 in 250; women with a accident greater than 1 in 250 were automatically advised awning positive. Additional admittance belief were affectionate age ≥18 years, article pregnancy, medical advantage by the civic healthcare arrangement of France, and evolution amid 11 and 18 weeks.

Women assigned to abide cfDNA testing provided claret samples; women in the invasive prenatal ysis accumulation underwent karyotyping performed at a cytogenetic laboratory. Genomic DNA was extracted from 5mL of plasma; sequencing of a ascendancy sample of 11 patients with trisomy 21 was performed application an centralized accurate method.

The primary aftereffect was abortion afore 24 weeks’ gestation; accessory outcomes included cardinal and allotment of invasive procedures performed in both ysis groups, achievement

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